Quantcast
atla.doereport.comatla.doereport.comMedication Metabolism - Medical Animation
Medication Metabolism - Medical Animation



or
Search Language
Browse
Medical Illustrations
Medical Exhibits
Medical Animations
Medical Animation Titles
Medical Encyclopedia
Custom Interactive
Most Recent Uploads
Body Systems/Regions
Anatomy & Physiology
Cells & Tissues
Abdomen
Back and Spine
Foot and Ankle
Hand and Wrist
Head and Neck
Hip
Knee
Shoulder
Thorax
Medical Specialties
Anesthesiology
Cancer
Cardiology
Dentistry
Emergency Medicine
Gastroenterology
Infectious Diseases
Neurology/Neurosurgery
Nursing Home
Ob/Gyn
Orthopedics
Pathology
Pediatrics
Personal Injury
Plastic Surgery
Psychiatry
Radiology
Surgery
Urology/Nephrology
Account
Administrator Login
 
6/2/20
Medication Metabolism - Medical Animation
 
This animation may only be used in support of a single legal proceeding and for no other purpose. Read our License Agreement for details. To license this animation for other purposes, click here.

If animation does not play, download and install the latest free Flash Player plugin.
More Like ThisAdd To Lightbox ANM11010 Enlarge Share
Ready to Purchase?

$999.00

Order by phone: (800) 338-5954
Item #ANM11010Source #1136

Medication Metabolism - Medical Animation
MEDICAL ANIMATION TRANSCRIPT:
Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪

YOU MAY ALSO WANT TO REVIEW THESE ITEMS:
Liver Biopsy
Liver Biopsy - ANH00025
Medical Animation
Add to my lightbox
Find More Like This
Treatments for Type 1 Diabetes
Treatments for Type 1 Diabetes - ANH16177
Medical Animation
Add to my lightbox
Find More Like This
Treatments for Type 2 Diabetes
Treatments for Type 2 Diabetes - ANH16178
Medical Animation
Add to my lightbox
Find More Like This
Medication Excretion
Medication Excretion - ANM10007
Medical Animation
Add to my lightbox
Find More Like This
Medication Absorption
Medication Absorption - ANM11011
Medical Animation
Add to my lightbox
Find More Like This
Pharmacodynamics - Pharmacokinectics
Pharmacodynamics - Pharmacokinectics - ANM11012
Medical Animation
Add to my lightbox
Find More Like This
What attorneys say about MLA and The Doe Report:
"I have a medical illustration created by Medical Legal Art at the beginning of every case to tell the client's story, usually before I depose the defendant doctor. The work product and cost-efficiency are outstanding. It is a situation where, as a trial lawyer, I don't leave home without it."

Rockne Onstad
Attorney at Law
Austin, TX

"The Doe Report is a visual feast of medical information for personal injury lawyers."

Aaron R. Larson, Esq.
President
ExpertLaw.com

"Medical Legal Art has always performed quality and efficient work. The doctors that review the exhibits are always amazed at the precise descriptions and drawings."

Michael Beckman
Viles Law Firm, P.A.
Fort Meyers, FL

"Your firm is great to work with and, most importantly for me, you get the job done on time and with the utmost professionalism. You should be proud of all those you employ, from KJ to Ben B. I've been especially pleased over the years with the work of Brian and Alice, both of whom seem to tolerate my idiosycratic compulsion to edit, but I've not found a bad apple in the bunch (and, as you know, I've used your firm a bunch!). I look forward to our continued professional relationship."

Kenneth J. Allen
Kenneth Allen & Associates
Valparaiso, IN

Medical Legal Blog |Find a Lawyer | Hospital Marketing