atla.doereport.comatla.doereport.comAlzheimer's Disease - Medical Animation
Alzheimer's Disease - Medical Animation



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6/20/21
Alzheimer's Disease - Medical Animation
 
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Alzheimer's Disease - Medical Animation
MEDICAL ANIMATION TRANSCRIPT:

The brain's cognitive functions include memory, which is the process of information retention and retrieval. Memories form in the hippocampus, which consists of information-processing cells called neurons. Each neuron receives chemical messages from other neurons via dendrites, then converts the message to an electrical charge called an action potential. In the space between them, neurons release stimulatory chemicals called neurotransmitters, which bind with receptors on the receiving cell and transfer information. Alzheimer's disease is a gradual, degenerative brain condition in which neurons in the memory and other cognitive areas of the brain lose function and die, resulting in progressive memory loss first, then difficulties learning and communicating, and, eventually, failing basic functions like breathing. In healthy neurons, enzymes help process a protein called amyloid precursor protein into fragments which help with normal cell function. In Alzheimer's, abnormal enzymatic processing produces fragments that include a sticky peptide called beta amyloid. Beta amyloid accumulates in the extracellular space, forming clumps called amyloid plaques. These clumps block the electrical and chemical connections between neurons. Inside healthy neurons, microtubules and tau proteins form an orderly structure that carries ions and nutrients within the cell. In Alzheimer's, chemical changes inside the neurons damage tau, twisting microtubules abnormally into neurofibrillary tangles, which disrupts ion and nutrient delivery within the cell. As the plaques and tangles multiply throughout brain tissue, neural connections diminish, and the malnourished cells lose function, resulting in widespread neural death, reduced brain mass, and severe cognitive and functional impairment. There is no cure for Alzheimer's, but current treatments include cholinesterase inhibitors, which delay the breakdown of acetylcholine, a neurotransmitter important for memory and learning, and antiglutamatergic medications, which regulate the activity of glutamate, another neurotransmitter essential for memory and learning, by blocking excessive glutamate binding to neurons, thus preventing neuronal dysfunction and death. ♪ [music] ♪

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What attorneys say about MLA and The Doe Report:
"It is with great enthusiasm that I recommend Medical Legal Art. We have used their services for three years and always found their professionalism, quality of work, and timely attention to detail to exceed our expectations. We recently settled two complicated catastrophic injury cases. One medical malpractice case involving a spinal abscess settled for 3.75 million and the other involving injuries related to a motor vehicle accident settled for 6.9 million. We consider the artwork provided by MLA to have been invaluable in helping us to successfully conclude these cases.

I highly recommend MLA to anyone seeking high quality, detailed medical legal artwork."

E. Marcus Davis, Esq.
Davis Zipperman, Krischenbaum & Lotito
Atlanta, GA
www.emarcusdavis.com

"Thank you for the wonderful illustrations. The case resulted in a defense verdict last Friday. I know [our medical expert witness] presented some challenges for you and I appreciate how you were able to work with him."

Robert F. Donnelly
Goodman Allen & Filetti, PLLC
Richmond, VA

"I thought you might want to know that after we sent a copy of your illustration to the defendants, with a copy to the insurance company, they increased their offer by an additional million dollars and the case was settled for $1,900,000.00.

I appreciate your help!"

O. Fayrell Furr, Jr.
Furr, Henshaw & Ohanesian
Myrtle Beach, SC
www.scmedicalmalpractice.com

"Medical illustrations are essential during trial for any medical malpractice case. The people at MLA have the uncanny ability of creating medical illustrations that simplify the most complex of medical concepts and human anatomy to a lay audience. The exhibits of MLA allow experts to easily describe complex concepts and human anatomy in a manner that could not be done otherwise.

In addition, their custom illustrations show in great detail the extent of injuries suffered and the devastating effects they have had on the client's anatomy. These custom illustration can show, side by side, the body before and after a catastrophic injury. The effect of this juxtaposition is unmatched by any testimony that can be adduced at the time of trial.

Even jurors after trial have commented on the ease with which they grasp medical concepts and anatomy once the MLA exhibits were introduced and used by my experts. Even judges who have "seen it all" are thoroughly impressed by the detail and sophistication of the illustrations.

I would not want to try a case without them."

Lambros Y. Lambrou
McHUGH & LAMBROU, LLP
New York, NY

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