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Osteoporosis - Medical Animation

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Osteoporosis - Medical Animation
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Osteoporosis - Medical Animation
MEDICAL ANIMATION TRANSCRIPT: Bone consists of a dense, compact layer and a spongy cancellous structure. While compact bone forms an organized outer shell, cancellous bone consists of thin, interlocking plates, called trabeculae. Osteoblasts and osteoclasts are the osteocytes, or bone cells, that make up bone tissue. Bone continually renews its structure and strength through remodeling. Osteoclasts break down existing bone, and osteoblasts built up new bone. In normal bone, adequate physical stress and changing blood calcium levels prompt osteocytes to initiate bone remodeling. Osteoblasts emit a cytokine that transforms immature osteoclasts into mature osteoclasts. In a process called resorption, mature osteoclasts use enzymes to remove existing bone tissue. Then osteoclasts release chemicals that stimulate immature osteoblasts to mature and release osteoprotegerin, a protein that deactivates osteoclasts, stopping bone resorption. In response, bone formation occurs. Mature osteoblasts deposit osteoid, a matrix that contains minerals, such as calcium and phosphorous, and a strong, flexible protein called collagen. Calcium and phosphorus crystallize or mineralize the osteoid, then transform into sturdy hydroxyapatite crystals, completing the bone formation process. In both men and women, before mid-life, bone resorption and bone formation are balanced. Hormones and other factors influence bone remodeling. For example, estrogen hormone suppresses osteoclasts, inhibiting resorption to help maintain bone strength. After mid-life, estrogen levels fall, and osteoclast activity may go unchecked. Increased resorption can lead to bone loss. Osteoporosis is a progressive disease in which the rate of bone resorption exceeds bone formation. As a result, the trabeculae in cancellous bone become fewer and farther apart. The compact bone thins, and overall, the bone becomes weak, fragile, and prone to fractures. Treatments for osteoporosis include calcium and vitamin D supplements to help maintain blood calcium levels, anti-resorptive medications that promote bone strength by preventing osteoclast activation and excessive resorption, anabolic medications, which increase osteoblast activity and promote bone formation, and exercise, including weight-bearing activities, which adds stress to bone, promoting remodeling. ♪ [music] ♪

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"I just wanted to let you know that after several days on trial, I settled [my client's] construction accident case for $4.5 million. Immediately after the jury was discharged, I spoke with several jurors who told me that they really appreciated the medical illustrations for their clarity in dealing with [my client's] devastating injuries. They also expressed their gratitude in being able to read from a distance all of the notations without difficulty. Obviously, the boards were visually persuasive. I am certain that this contributed to our successful result."

Michael Gunzburg, Esq.
Attorney at Law.
New York, NY

"It is with great enthusiasm that I recommend Medical Legal Art. We have used their services for three years and always found their professionalism, quality of work, and timely attention to detail to exceed our expectations. We recently settled two complicated catastrophic injury cases. One medical malpractice case involving a spinal abscess settled for 3.75 million and the other involving injuries related to a motor vehicle accident settled for 6.9 million. We consider the artwork provided by MLA to have been invaluable in helping us to successfully conclude these cases.

I highly recommend MLA to anyone seeking high quality, detailed medical legal artwork."

E. Marcus Davis, Esq.
Davis Zipperman, Krischenbaum & Lotito
Atlanta, GA

"I wanted to take some time out to let you know what a wonderful job you did with the 'collapsed lung/fractured rib' illustrations. They were both detailed and accurate. My medical expert was comfortable working with them and he spent at least an hour explaining to the jury the anatomy of the lungs, the ribs and the injuries depicted in the illustrations. Needless to say, the jury was riveted to the doctor during his testimony.

The jury returned a verdict for $800,000.00 and I'm sure we would not have done so well if not for the visualizations we were able to put forth with your assistance. Lastly, my special thanks to Alice [Senior Medical Illustrator] who stayed late on Friday night and patiently dealt with my last minute revisions."

Daniel J. Costello
Proner & Proner
New York, NY

"I would like to thank all of you at Medical Legal Art for all the assistance you provided. It was a result of the excellent, timely work that we were able to conclude the case successfully.

I feel very confident that our paths will cross again."

Fritz G. Faerber
Faerber & Anderson, P.C.
St. Louis, MO

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